Explore our core high-purity raw materials manufactured under strict GMP standards.
Icaritin (CAS No: 118525-40-9, Molecular Formula: C21H20O6) is a highly potent, bioactive prenylflavonoid derivative derived from the genus Epimedium (commonly known as Horny Goat Weed). Unlike its precursor molecule, Icariin, Icaritin represents the aglycone form, obtained through enzymatic hydrolysis or chemical cleavage of the sugar moieties. This structural transformation significantly enhances its bioavailability, metabolic stability, and affinity for cellular receptors.
In recent years, global pharmacological research has highlighted Icaritin's multi-target therapeutic potential. It operates as a selective estrogen receptor modulator (SERM), exhibits powerful anti-inflammatory properties by inhibiting the IL-6/JAK/STAT3 signaling pathway, and demonstrates significant promise in oncology, longevity science, and neuroprotection. As a leading China Icaritin Powder Manufacturer, we provide high-purity, standardized Icaritin powder tailored for pharmaceutical research, dietary supplements, and functional food formulations.
"The transition from Icariin to Icaritin represents a milestone in phytomedicine, offering superior pharmacokinetics and targeted cellular pathways for modern therapeutic applications."
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a premier, technology-driven enterprise specializing in the research, development, production, and global distribution of high-quality herbal extracts and their derivatives. With over 20 years of industry experience, TRB has established itself as a trusted partner for global pharmaceutical, nutraceutical, and cosmetic brands.
Our comprehensive product portfolio includes premium Herbal extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice powder, Essential oils, and Bee Products. Our commitment to scientific innovation, strict quality control, and customer-centric service has earned us the prestigious 2026 "Global Biotechnology and Life Sciences Award" - ''Best Global Herbal Extract Provider 2026''.
TRB operates three state-of-the-art manufacturing facilities: a dedicated herbal extract factory, a specialized bee products facility, and an advanced animal extract facility. All operations are fully compliant with international quality standards, backed by a comprehensive suite of certifications including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER.
How TRB leverages smart manufacturing and vertical integration to secure global supply chains.
Our facilities utilize closed-loop, automated countercurrent extraction lines. This ensures minimal human contact, precise temperature control, and optimal yield consistency across production batches.
We implement eco-friendly solvent recovery systems, reducing environmental impact while maintaining solvent residue levels far below USP and EP regulatory limits.
Every batch of Icaritin powder is subjected to rigorous HPLC, GC-MS, and ICP-MS testing. Our digital batch record system guarantees complete traceability from raw Epimedium harvest to final packaging.
In an era of geopolitical volatility and climate-induced agricultural shifts, supply chain resilience is paramount. TRB mitigates these risks through strategic raw material cultivation partnerships across China's premier geographical regions for Epimedium growth. By controlling the supply chain from seed to active ingredient, we shield our global clients from price volatility and quality fluctuations.
Our logistics network is optimized for rapid international clearance, utilizing temperature-controlled shipping and double-layered vacuum packaging to preserve the chemical integrity of our Icaritin powder during transit. Whether you require air freight for urgent R&D phases or sea freight for commercial-scale manufacturing, TRB ensures seamless delivery.
The global demand for high-purity Icaritin is experiencing exponential growth, driven by its expanding role in several high-value sectors:
As the global population ages, the demand for cognitive health solutions is surging. Icaritin has demonstrated neuroprotective properties by modulating neuroinflammation and promoting synaptic plasticity. It is increasingly formulated into premium nootropic stacks aimed at memory retention, focus, and long-term brain health.
Longevity science is transitioning from a niche market to a mainstream industry. Icaritin acts as a potent activator of sirtuins and AMPK pathways, which are critical regulators of cellular aging and metabolic homeostasis. This makes it a highly sought-after ingredient for next-generation anti-aging supplements.
One of the most groundbreaking developments for Icaritin is its clinical evaluation in oncology. Research indicates that Icaritin modulates the tumor microenvironment, inhibits immune evasion, and synergizes with traditional immunotherapies. This clinical-grade application requires manufacturers to supply exceptionally high purity levels (98%+ HPLC), a standard that TRB consistently delivers.
Historically, Epimedium extracts have been used to support vitality and reproductive health. Icaritin, as the primary active metabolite, offers a refined, highly concentrated solution for men's health formulations, providing predictable efficacy without the variability associated with crude plant extracts.
TRB Icaritin Powder is manufactured to meet the most stringent international pharmacopoeia standards.
TRB's products have been successfully exported to more than 60 countries and regions across North America, Europe, Asia-Pacific, and Latin America. We have established long-term strategic partnerships with leading pharmaceutical companies and supplement brands who rely on our consistent quality and regulatory documentation.
Our dedicated regulatory affairs team provides comprehensive support, including the preparation of Drug Master Files (DMF), Technical Construction Files (TCF), and detailed Certificates of Analysis (CoA) for every batch. This ensures that our clients can navigate local regulatory frameworks (such as FDA, EFSA, and TGA) with ease.
We are fully committed to the research and development of pure natural plant extracts, dedicating our scientific expertise to the health and well-being of all humanity.
Get answers to technical, commercial, and regulatory questions regarding Icaritin sourcing.
Icariin is a glucoside (a molecule bound to sugar molecules) extracted directly from Epimedium. Icaritin is the aglycone form of Icariin, meaning the sugar molecules have been removed. This structural difference makes Icaritin significantly more bioavailable, chemically stable, and active at the cellular level compared to Icariin.
We manufacture Icaritin powder in various standardized specifications, ranging from 10% to 98% purity. For pharmaceutical research and advanced supplement formulations, we recommend our ultra-high purity 98% HPLC-grade crystalline powder.
TRB's manufacturing facilities operate under strict GMP compliance and hold ISO, HACCP, ORGANIC, FDA registration, HALAL, and KOSHER certificates. We provide full documentation packages for regulatory audits.
Our standard MOQ for commercial orders is 25kg (packaged in fiber drums). However, for R&D phases and pilot testing, we can accommodate sample orders starting from 1kg.
Every batch of raw Epimedium is tested before extraction. The final Icaritin powder undergoes Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for heavy metals and Gas Chromatography-Mass Spectrometry (GC-MS) for pesticide residues, ensuring compliance with USP, EP, and ChP limits.
Our Icaritin powder has a shelf life of 24 months when stored in its original, unopened packaging in a cool, dry place away from direct sunlight and moisture.
Yes, TRB offers comprehensive OEM/ODM solutions, including custom particle sizing (micronization), custom packaging, and formulation blending to meet your specific product requirements.
Explore our wider range of high-performance botanical extracts and powders.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
Phone: 86-25-52863298
Mobile: 86-13770771528
Fax: 86-25-52867040
Get in touch with our technical sales team for custom quotes, specification sheets, and sample requests.
