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Piperlongumine (also known as Piplartine) is a naturally occurring amide alkaloid purified from the fruit of the long pepper (Piper longum). In recent years, this molecule has emerged as a cornerstone of advanced pharmacological research and functional ingredient formulation. Its unique chemical structure allows it to selectively target aberrant cells while leaving healthy tissue unharmed.
As a leading China Piperlongumine Powder Manufacturer, we leverage advanced extraction and crystallization technologies to deliver a product with a purity level exceeding 98% (HPLC). Our powder is widely utilized in senolytic research, neuroprotection studies, and next-generation dietary supplements aiming to modulate oxidative stress pathways.
By selectively elevating Reactive Oxygen Species (ROS) in targeted cells, Piperlongumine acts as a highly specific biological modulator. This mechanism has positioned it as a premium asset for global biotech firms, academic research institutions, and innovative nutraceutical brands.
Our proprietary extraction process combines green chemistry principles with high-throughput purification to ensure maximum yield and purity.
We source premium *Piper longum* fruits directly from verified agricultural partners. Each batch undergoes rigorous botanical identification and pesticide residue screening.
Utilizing state-of-the-art supercritical fluid extraction (SFE) technology to isolate raw alkaloids without the use of toxic chlorinated solvents.
The raw extract is subjected to temperature-controlled fractional crystallization, concentrating the Piperlongumine content to over 95%.
Final purification via preparative HPLC ensures a minimum purity of 98%. The product is vacuum-dried and micronized in a Class 100,000 cleanroom.
Understanding the market dynamics, growth drivers, and industrial demand for high-purity Piplartine.
Piperlongumine is recognized as a potent senolytic agent that selectively clears senescent cells. This has triggered massive demand from longevity biotech firms worldwide.
Its ability to cross the blood-brain barrier and modulate neuroinflammatory pathways makes it a highly sought-after ingredient for premium cognitive enhancement supplements.
As a selective ROS inducer, Piperlongumine serves as a reference compound in cancer biology research, driving consistent demand from academic and clinical laboratories.
How global brands integrate our Piperlongumine Powder into market-ready products.
In the US and Canada, Piperlongumine is increasingly formulated alongside Quercetin, Fisetin, and Resveratrol in premium "cellular rejuvenation" capsules. Our micronized powder ensures optimal bioavailability and seamless blending in dry-powder mixes.
European brands utilize our allergen-free, non-GMO Piperlongumine to target the premium nootropic segment. Strict adherence to EU heavy metal and pesticide regulations makes our powder the preferred choice for European distributors.
In Japan and South Korea, research into the anti-inflammatory properties of Piplartine has led to its inclusion in high-end topical formulations targeting skin aging and oxidative stress protection.
We supply standardized, high-purity reference batches to CROs globally, facilitating high-throughput screening and in-vitro assays with highly reproducible results.
In today's volatile global market, supply chain stability is paramount. Our manufacturing infrastructure in China provides unparalleled advantages in terms of cost-efficiency, raw material security, and scaling capacity.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is the leading China manufacturer and exporter of herbal extracts and their derivatives for more than 20 years.
TRB is a technology-based company that combines research and development, production, and international market sales. Our extensive product portfolio includes Herbal extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice powder, Essential oil, and Bee Products.
Thanks to TRB's rapid development and dedicated service in the plant extract industry over the years, we have been honored with the 2026 "Global Biotechnology and Life Sciences Award" - "Best Global Herbal Extract Provider 2026".
TRB currently operates three specialized factories: one dedicated to herbal extracts, one for bee products, and another for animal-derived extracts. Our facilities hold a comprehensive suite of international certifications, including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER Certificates.
In recent years, TRB has focused heavily on the research and development of Nootropics, Brain Health Herb Extracts, Anti-Aging Herb Extracts, and Longevity Herb Extracts, receiving outstanding feedback from our global clientele.
How we guarantee the purity, safety, and regulatory compliance of every batch we ship.
Every batch of Piperlongumine Powder is subjected to rigorous testing, including HPLC for purity, ICP-MS for heavy metals, and GC-MS for residual solvents.
We provide comprehensive documentation support, including COA, MSDS, Allergen Statements, Non-GMO declarations, and complete BSE/TSE-free certification.
Available in 1kg aluminum foil bags for R&D and 25kg fiber drums for commercial production. Nitrogen flushing is available to maximize shelf-life stability.
Expert answers to common technical, commercial, and regulatory questions about Piperlongumine Powder.
Discover more premium natural ingredients manufactured at our state-of-the-art facilities.
Connect with our technical sales department for specifications, pricing, and sample requests.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
86-25-52863298
86-13770771528
86-25-52867040
