China Nefiracetam Manufacturer, Supplier

Product Overview

Nefiracetam (CAS 77191-36-7) is a synthetic pyrrolidone derivative and a potent nootropic agent with multimodal neuroenhancing properties. Developed initially for Alzheimer’s disease, it is now widely studied for cognitive enhancement, neuroprotection, and anticonvulsant applications.

Cognitive Enhancement

Improves memory, focus, and learning capacity through GABAergic, cholinergic, and monoaminergic pathways.

Neuroprotective Effects

Reduces neuronal damage in ischemic conditions and inhibits beta-amyloid-induced inflammation.

Anticonvulsant Activity

Suppresses Ro 5-4864-induced seizures and amygdala-kindled seizures in preclinical models.

Phase 2 Clinical Trials

Under investigation for cerebrovascular disorders and post-stroke depression.

Chemical & Pharmacological Profile

Molecular Specifications

Molecular Formula: C₁₄H₁₈N₂O₂ | Molecular Weight: 246.3 g/mol

Solubility

DMSO: 24.6 mg/mL (100 mM)
Ethanol: 24.6 mg/mL (100 mM)
Water: 5 mg/mL (limited solubility)

Mechanism of Action

Enhances L/N-type calcium channel activity and nicotinic acetylcholine receptor (nAChR) function.
Modulates PKC and PKA pathways to promote hippocampal synaptic plasticity.
Increases GABAergic transmission and glutamate release for neuroprotection.

Applications in Research

1 Cognitive Studies

Improves passive avoidance retention and reverses scopolamine-induced amnesia in rodents.
Enhances language learning via speech center modulation.

2 Neurological Disorders

Reduces apathy and psychiatric symptoms in stroke patients.
Potential therapy for Alzheimer’s, Parkinson’s, and age-related cognitive decline.

3 Anticonvulsant Research

Inhibits seizure propagation in amygdala-kindled models (IC₅₀ data available upon request).

Safety & Handling

GHS Classification

Acute Oral Toxicity Category 4 (H302). Not classified as hazardous for transport.

Handling Precautions

Avoid inhalation, skin/eye contact. Use PPE (gloves, N95 mask) in well-ventilated areas.
Store at -20°C (powder, 3-year stability) or -80°C (solution, 2-year stability).

Disposal

Comply with local regulations for chemical waste (EPA/DOT guidelines).

Key Product Specifications & Advantages

High Purity

>98% verified by HPLC analysis

Global Compliance

Meets USP, FDA, and EMA standards for research use

Bulk Availability

25 mg to 1 g packaging with expedited shipping options

Frequently Asked Questions

What is Nefiracetam and what is its CAS number?

Nefiracetam is a synthetic pyrrolidone derivative and a potent nootropic agent with multimodal neuroenhancing properties. Its CAS Registry Number is 77191-36-7.

What are the key chemical parameters of Nefiracetam?

Nefiracetam has a molecular formula of C₁₄H₁₈N₂O₂ and a molecular weight of 246.3 g/mol.

How soluble is Nefiracetam in different solvents?

Nefiracetam is highly soluble in DMSO and Ethanol at 24.6 mg/mL (100 mM). It has limited solubility in water (5 mg/mL).

What are the storage guidelines for Nefiracetam?

For long-term stability, keep Nefiracetam powder stored at -20°C (stable for up to 3 years). Solutions should be stored at -80°C (stable for up to 2 years).

What standards does this product meet?

The Nefiracetam compound features high purity (>98% verified by HPLC) and complies with USP, FDA, and EMA quality standards for laboratory research applications.

Nootropic agent Cognitive enhancer GABAergic modulator Neuroprotective compound Anticonvulsant drug Phase 2 clinical trials Alzheimer’s research Synaptic plasticity Ro 5-4864 antagonist