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N-Boc-O-Benzyl-D-serine is a protected derivative of D-serine, widely used in peptide synthesis and pharmaceutical research. Its tert-butoxycarbonyl (Boc) and benzyl (Bzl) groups provide dual protection for the amino and hydroxyl functionalities, ensuring stability during complex synthetic processes.
It is a protected derivative of D-serine widely used as a key reagent in solid-phase and solution-phase peptide synthesis, as well as a pharmaceutical intermediate for developing chiral drugs and enzyme inhibitors.
The product features a purity of ≥98% (measured by HPLC), a molecular weight of 295.33 g/mol, and appears as a white crystalline powder. The CAS number is 47173-80-8.
To ensure stability, the powder should be stored at -20°C in a dry, dark, and sealed container. The Boc and benzyl protection groups help maintain chemical integrity under these conditions.
In solid-phase synthesis, the benzyl group is cleaved along with the resin using HF or TFMSA. In solution-phase synthesis, hydrogenolysis selectively removes the benzyl group while leaving the Boc group intact.
Yes, it is not classified as hazardous under IMDG/IMO regulations for transportation. It complies with REACH, TSCA, ISO standards, and is listed in China’s Chemical Inventory.
