Chastertree Extract, scientifically derived from the fruit of Vitex agnus-castus (often referred to as Chasteberry or Monk's Pepper), is a premier botanical active ingredient widely utilized in the global nutraceutical, pharmaceutical, and functional food sectors. Standardized primarily to active biomarkers such as Agnuside and Aucubin, this extract represents a cornerstone for women's endocrine health formulations.
For decades, clinical research has highlighted Chastertree Extract's mechanism of action in modulating the pituitary-ovarian axis. By binding to dopamine D2 receptors in the anterior pituitary gland, it inhibits the release of prolactin, thereby balancing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) profiles. This therapeutic cascade aids in regulating progesterone levels, providing natural management for premenstrual syndrome (PMS), cyclical mastalgia, premenstrual dysphoric disorder (PMDD), and menopausal transition symptoms.
Below is the default industrial profile for high-purity Chastertree (Chasteberry) Extract offered by premium Chinese manufacturers.
| Specification Parameter | Standard Metric / Limit | Testing Method (USP / EP) |
|---|---|---|
| Botanical Source | Vitex agnus-castus L. (Fruit) | Macroscopic / HPTLC Identification |
| Active Assay (Agnuside) | ≥ 0.5% (Custom concentrations available up to 5.0%) | HPLC-DAD |
| Active Assay (Aucubin) | ≥ 0.6% Standardized Base | HPLC |
| Physical Appearance | Fine Yellowish-Brown to Brown Powder | Visual Inspection |
| Solubility Profile | Hydro-ethanolic soluble (Optimized for dietary supplements) | Gravimetric / Solubility Assay |
| Heavy Metals (Total) | ≤ 10.0 ppm (Pb ≤ 0.5 ppm, As ≤ 0.1 ppm, Cd ≤ 0.1 ppm, Hg ≤ 0.1 ppm) | ICP-MS |
| Pesticide Residues | Compliant with USP <561> and EC Regulation 396/2005 | GC-MS / LC-MS |
| Microbiological Profile | Total Plate Count ≤ 1,000 cfu/g; Yeast & Mold ≤ 100 cfu/g; E. Coli Negative | USP <2021> / <2022> |
China has solidified its position as the global powerhouse for plant extract manufacturing, offering a unique fusion of agricultural abundance, technological innovation, and cost-efficiencies. When sourcing Chastertree Extract, Chinese B2B suppliers present structural advantages that guarantee high ROI for international buyers:
Chinese manufacturers establish extensive agricultural cooperative zones and scientific crop-monitoring initiatives, guaranteeing a stable, non-GMO, and sustainable harvest of high-potency Vitex raw berries yearly.
By leveraging advanced technologies such as supercritical fluid extraction (SFE), membrane filtration, and automated column chromatography, Chinese facilities achieve precise isolation of active phytochemicals.
Industrial concentration and robust logistic infrastructure in key economic zones drive down utility and shipping costs, passing substantial wholesale savings directly to pharmaceutical and nutraceutical buyers.
Global brand owners, sourcing directors, and formulation scientists face multi-dimensional challenges when procuring botanical ingredients. Regulatory changes and consumer demands require raw materials that meet strict safety profiles:
Navigating regional customs and food agency guidelines requires experience and compliance protocols. Top-tier Chinese manufacturers now offer localized supply chains and regulatory consulting to simplify entry into major global economies:
Suppliers guarantee compliance with FSMA guidelines, offer U.S. FDA facility registrations, and confirm raw materials meet DSHEA criteria. Materials undergo third-party verified testing (e.g., Eurofins, SGS) prior to customs clearance, mitigating regulatory risks.
Extracts comply strictly with the European Pharmacopoeia (EP) monograph standards, maintaining PAH limits (benzo[a]pyrene ≤ 10 ppb) and strict pesticide trace regulations. Complete traceability dossiers support product registrations under EMA botanical monographs.
Easily formulated into consumer-friendly gummy bases. High solubility and standardized profiles ensure consistent serving sizes in active daily doses.
Flowable dry powder form with ideal bulk density, designed for high-speed capsule encapsulation machines without binding or clumping.
Perfect for inclusion in functional beverage mixes. Minimal sensory impact when formulated with flavoring systems.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a leading China manufacturer and exporter of herbal extracts and derivatives, bringing over 20 years of industry expertise to the global marketplace.
As a technology-focused enterprise, TRB integrates botanical research and development, manufacturing, and global distribution. Our portfolio spans Herbal Extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice Powders, Essential Oils, and Bee Products.
Driven by continuous modernization and dedicated customer service, TRB was awarded the prestigious Global Biotechnology and Life Sciences Award — "Best Global Herbal Extract Provider". We operate three specialized production facilities (herbal extract, bee products, and animal extract), with certifications including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER.
In recent years, our R&D efforts have focused on anti-aging compounds, longevity matrices, and brain health (nootropics), delivering certified, functional ingredients to partners in over 60 countries.
Our standard standardized Chastertree (Chasteberry) Extract is produced utilizing a hydro-ethanolic solvent ratio (typically 70% Food-Grade Ethanol and 30% Water). This ratio ensures optimal extraction of active iridoid glycosides (Agnuside and Aucubin) while minimizing residual solvents, ensuring full compliance with USP <467> guidelines.
We employ a strict identity validation protocol on all raw incoming Vitex agnus-castus berries. Each harvest batch is screened for target weeds known to contain Pyrrolizidine Alkaloids. Furthermore, our final powders undergo LC-MS/MS testing to guarantee non-detectable levels of major PAs, ensuring compliance with strict European limits.
For standard grades (e.g., 0.5% Agnuside), our standard minimum order quantity (MOQ) is 25 kilograms, packaged in secure double food-grade LDPE liners inside fiber drums. For custom specifications, formulation trials, or pilot runs, we can accommodate smaller pilot batches upon validation.
Yes. Our facilities undergo annual audits by recognized certification bodies. We issue batch-specific Kosher and Halal certificates alongside the Certificate of Analysis (COA) with each export consignment.
Our Chastertree Extract has a validated shelf life of 24 months from the date of manufacture, provided it is stored in the original, unopened container in a cool, dry environment (relative humidity below 60%) away from direct heat, sunlight, and humidity.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
86-25-52867040
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