Global Bio-Tech Ingredient Solutions

China OEA Manufacturer & Premium Extract Supplier

Premium Biological & Herbal Extracts Portfolio

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GLOBAL BIOTECHNOLOGY AWARD WINNER

Leading China Manufacturer of Oleoylethanolamide (OEA) & Bioactives

Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is China's premier manufacturer and exporter of standard, custom, and highly refined herbal extracts, pharmaceutical intermediates, and functional lipids such as Oleoylethanolamide (OEA). With an established track record spanning more than 20 years, TRB represents the highest tier of production capability and scientific integration in China's bio-tech landscape.

Our operation seamlessly integrates research and development, pilot-scale synthesis, industrial-scale extraction, and direct global distribution. This fully vertical integration allows us to supply the global market with elite bioactives, food additives, and nutritional raw materials, ensuring total control over purity, heavy metal parameters, pesticide limits, and product stability.

Due to our continuous dedication to optimizing natural active ingredients and providing comprehensive solution support, we are proud to be the recipient of the prestigious 2026 "Global Biotechnology and Life Sciences Award" - ''Best Global Herbal Extract Provider 2026''.

TRB R&D Center TRB Plant Tour
20+ Years Industry Experience
3 GMP Standard Factories
60+ Exporting Countries
99% Purity Level Capabilities

TRB operates three state-of-the-art manufacturing facilities. Our flagship factory specializes in premium herbal extraction and chemical synthesis (including Oleoylethanolamide / OEA); our second plant focuses on high-purity bee products; and our third facility is dedicated to advanced animal-derived extract processing. This diverse structural layout enables us to power global brands across five continents with certified bio-ingredients.

Understanding Oleoylethanolamide (OEA): Mechanisms and Market Growth

Discover how this endogenous lipid molecule is transforming the global fat-burner and satiety supplement sectors.

PPAR-α Receptor Activation

OEA is a potent, naturally occurring lipid mediator that regulates food intake and body weight. It acts primarily by binding and activating Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α), which is essential for modulating fatty acid oxidation, lipid metabolism, and homeostatic energy balance.

Satiety Signal Induction

By activating sensory afferent fibers of the vagus nerve, OEA sends signal cascades to the central nervous system (specifically the hypothalamus and hindbrain), inducing a natural sense of fullness or satiety. This reduces daily calorie intake without causing central nervous system stimulation or jitteriness.

Synergistic Integration

As a clean ingredient, OEA serves as a primary base in modern formulations. B2B buyers pair OEA with metabolic boosters (such as Hawthorn Extract or Cassia Nomame) and cognitive agents (like Alpha GPC) to formulate comprehensive body composition solutions.

Why Choose TRB as Your China OEA Manufacturer?

Unlocking technological supremacy, vertical supply chain integration, and rigorous global compliance.

TRB Advanced Manufacturing Plant

1. High-Purity Synthesis & Crystallization

Our OEA (Oleoylethanolamide) is manufactured using modern condensation and crystallization methods. By carefully maintaining temperature, pressure, and solvent ratios, we yield OEA powder with an HPLC purity of ≥98% and extremely low residual solvents, matching strict USP and EU Pharmacopoeia guidelines.

2. State-of-the-Art Quality Control

Our laboratories are equipped with Ultra-Performance Liquid Chromatography (UPLC), Gas Chromatography-Mass Spectrometry (GC-MS), and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). This ensures that every batch of OEA has zero contamination, verified heavy metal parameters (Pb < 1ppm, As < 1ppm), and compliant microbiological assays.

3. Unrivaled Cost Efficiency at Scale

With an annual production capacity of hundreds of metric tons across our 3 factories, TRB leverages scale economies. Our direct raw material procurement contracts and optimized industrial synthesis pathways significantly lower production costs compared to Western alternatives, passing the savings to our partners.

Macro Solutions & Localized Formulation Applications

How our enterprise clients across the USA, EU, and APAC leverage TRB ingredients in their regional markets.

Weight Management Solutions

By blending OEA with Hoodia Gordonii Extract and Cassia Nomame Extract, brands create dual-action fat burners that simultaneously suppress appetite and inhibit lipase activity, offering a dual metabolic pathway approach.

Nootropic & Mind-Muscle Formulations

We supply Alpha GPC Powder 99% and OEA as a stack for sports nutrition. While OEA aids cellular fat mobilization and metabolic focus, Alpha GPC optimizes acetylcholine levels, enhancing cognitive power and physical focus.

Metabolic & Cardiovascular Health

In the EU market, combining OEA with Hawthorn Leaf Extract or Vitis Vinifera Extract has gained significant traction. This synergy promotes arterial flexibility, healthy circulation, and natural fat utilization.

Quality Certificate Assessment
Packaging & Warehouse

International Compliance & Quality Certifications

TRB's facility processes are certified by the world's most demanding auditing bodies to ensure zero-risk global logistics.

GMP CERTIFIED ISO 9001 / ISO 22000 HACCP COMPLIANT ORGANIC CERTIFIED FDA REGISTERED HALAL / KOSHER

Regulatory Compliance & DMF Documentation

For pharmaceutical and high-end nutraceutical brands in the US and Europe, we provide comprehensive technical packages, including Drug Master Files (DMF) support, COA (Certificate of Analysis) for every batch, MSDS, Allergen Statements, and heavy metals declarations. This transparent documentation guarantees seamless FDA clearances and simplifies product registration processes.

Green Chemistry & Sustainable Sourcing

In accordance with global ESG mandates, TRB utilizes clean extraction technologies. We minimize carbon emissions through efficient water circulation systems, non-toxic organic solvents, and eco-friendly synthetic pathways. Our commitment guarantees that your brand's supply chain remains ethically sound and environmentally responsible.

Frequently Asked Questions: Bulk OEA Procurement

Answers to crucial technical, logistical, and regulatory questions from global B2B procurement professionals.

What is the standard purity of Oleoylethanolamide (OEA) manufactured by TRB?
At Nanjing Tong Rui Bio-Tech (TRB), we produce Oleoylethanolamide (OEA) powder with a standard purity rating of ≥98% using advanced HPLC test methods. We also offer custom specifications (e.g., 90%, 95%) depending on formulation requirements.
How does OEA differ from typical synthetic fat burners?
Unlike synthetic stimulants (such as caffeine or ephedrine) that raise blood pressure and heart rate, OEA works as an endogenous lipid mediator. It acts naturally on the PPAR-α receptor and stimulates vagal sensory nerves to signals satiety, avoiding stimulant-induced side effects.
What is the standard packaging and minimum order quantity (MOQ)?
Our standard bulk packaging is 25kg fiber drums lined with double-layered food-grade polyethylene bags. For initial trial formulations and testing, we support lower pilot MOQs (typically starting at 1kg to 10kg).
How does TRB guarantee heavy metal and pesticide compliance?
Every batch goes through heavy metal testing via Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and pesticide residue analysis. We adhere to stringent international standards, limiting total heavy metals to <10ppm and arsenic to <1ppm.
What is the typical shelf life and storage protocol for bulk OEA?
Our OEA has a verified shelf life of 24 months when stored in original unopened containers, kept away from direct sunlight, heat, and moisture. We recommend storing it at room temperature (below 25°C) in a dry place.
Can TRB provide customized formulations (OEM/ODM)?
Yes. We offer contract manufacturing, customized powder blends, and tailored granular meshes. This enables our clients to seamlessly transition raw OEA powder into capsules, tablets, or ready-mix sports formulations.

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Maximize your formulation potential with our highly concentrated functional powders and essential extracts.

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Visit Us

Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012

Call Us Directly

Tel: 86-25-52863298

Mobile: 86-13770771528

Fax Operations

Communication Icon 86-25-52867040

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