China Ursolic Acid Manufacturer & Factory

Global Standard Pentacyclic Triterpenoid Extract | Tailored Formulations for Bio-Pharma, Nutraceuticals & Cosmetics

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Global Commercial & Industrial Status of Ursolic Acid

Ursolic Acid (a natural pentacyclic triterpenoid carboxylic acid, C₃₀H₄₈O₃) is widely recognized as a highly versatile bio-active agent. Commonly extracted from natural sources such as Rosemary leaves (Rosmarinus officinalis), Apple peels, and Loquat leaves (Eriobotrya japonica), it has transitioned from a niche botanical compound to a cornerstone ingredient in multi-billion dollar sectors, including anti-aging therapeutics, metabolic management, dermatological repair, and clinical pharmacology.

According to current market intelligence, the global demand for high-purity Ursolic Acid (purity ≥ 98% HPLC) is experiencing a compound annual growth rate (CAGR) of over 6.8%. This surge is driven by its exceptional ability to modulate cell signalling pathways, specifically its action as an AKT pathway activator, anti-inflammatory modulator via NF-kB inhibition, and muscle-mass protector. Manufacturers across North America, Europe, and Asia-Pacific are actively securing clean-label, solvent-safe supply chains to fulfill the demands of regulatory bodies like the US FDA and the European Medicines Agency (EMA).

As a leading Chinese manufacturer, Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) addresses this global industrial demand by providing scalable, eco-friendly extraction techniques that yield exceptional purity levels with minimal carbon footprint, ensuring uninterrupted supply to research labs and large-scale manufacturing pipelines globally.

About Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB)

A twenty-year heritage of scientific excellence in botanical extraction and life science solutions.

Established with a vision to integrate scientific research with ecological manufacturing, Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is China's premier manufacturer and exporter of highly-purified herbal extracts and their derivatives, operating successfully for more than 20 years.

TRB is a technology-focused enterprise that seamlessly combines research and development (R&D), advanced industrial production, and international commercial operations. Our highly diversified product portfolio encompasses:

Herbal Extracts (including high-purity Ursolic Acid, Ginsenosides, and Apigenin)
Natural Sweeteners (Mogrosides, Steviol Glycosides)
Nootropic Compounds (Alpha GPC, Huperzine A, Brain Health Herb Extracts)
Vegetable & Fruit Juice Powders (processed using low-temperature spray drying)
Essential Oils & Bee Products (Royal Jelly, Propolis)

TRB's commitment to quality control and technical innovation has earned us the prestigious 2026 Global Biotechnology and Life Sciences Award, recognizing us as the "Best Global Herbal Extract Provider 2026".

20+ Years

Industry Leadership

Supplying standardized raw materials and customized extracts to the global market since 2004.

3 Factories

Dedicated Facilities

Independent herbal extraction, animal-derived extraction, and bee products refining sites ensuring zero cross-contamination.

60+ Countries

Global Export Footprint

Serving pharmaceutical, cosmetic, and nutritional brands across North America, Europe, and the APAC region.

Macro-Industry Solutions & Localized Applications

How high-grade Ursolic Acid addresses emerging challenges in global product formulation.

Biomedical & Oncology Therapeutics

Clinical studies show Ursolic Acid's potential to induce apoptosis in cancer cell lines and downregulate angiogenesis. Our high-purity (98% HPLC) grade serves as a key active pharmaceutical ingredient (API) precursor, ensuring consistent batch bio-activity for preclinical and clinical research.

Anti-Sarcopenia & Sports Nutrition

Sarcopenia (muscle wasting) affects aging populations. Ursolic Acid downregulates the genes responsible for muscle atrophy (MuRF-1 and Atrogin-1) while promoting IGF-1 signaling. TRB provides free-flowing, water-dispersible grades optimized for capsule, tablet, and powder blends.

Clinical Cosmeceuticals

In premium skincare, Ursolic Acid stimulates collagen synthesis, ceramides production, and epidermal barrier repair. It serves as an anti-photoaging and anti-wrinkle compound. TRB's ultra-purified powder ensures minimal color and odor contribution to skincare emulsions.

Technical Specification & Advanced Extraction Roadmap

Integrating green chemistry with precise chemical analytical standards.

Analytical Parameter	Specification (Standard Pure)	Specification (Premium Pharm Grade)	Methodology / Verification
Assay (Purity)	≥ 50% to 90% Ursolic Acid	≥ 98.0% Ursolic Acid	High Performance Liquid Chromatography (HPLC)
Appearance	Light green to yellow-green powder	White to off-white crystalline powder	Visual Inspection
Loss on Drying	≤ 5.0%	≤ 1.0%	USP <731> (105°C, 3 Hours)
Heavy Metals (as Pb)	≤ 10 ppm	≤ 5 ppm	ICP-MS (USP <233>)
Residual Solvents	Meets USP/EP Limits	Ethanol-only extraction, ≤ 500 ppm	GC-FID (USP <467>)

Step 1: Sustainable Raw Material Sourcing

We source top-tier, identity-verified Rosemary leaves (Rosmarinus officinalis) and Loquat leaves. Each batch undergoes rigorous DNA barcoding and pesticide screen analysis to ensure clean raw materials.

Step 2: Dual-Phase Eco-Extraction

Utilizing high-efficiency food-grade ethanol extraction combined with ultrasonic-assisted cavitation, isolating triterpenoids from structural plant fibers without using toxic solvents like hexane or chloroform.

Step 3: Column Chromatographic Purification

Our automated chromatography columns separate Ursolic Acid from its isomer, Oleanolic Acid. This separation allows us to achieve highly precise purity profiles up to 98.5%.

Step 4: Vacuum Drying & Cleanroom Milling

Drying occurs in vacuum conditions to prevent thermal degradation. Milling is performed inside a Class 100,000 GMP cleanroom, ensuring precise control over particle size distribution (PSD) and eliminating microbial contaminants.

Uncompromising Compliance & Certifications

For international buyers in the European Union, North America, and other regulated markets, ingredient compliance is critical. TRB mitigates regulatory risks through a comprehensive quality management system. Our three production plants operate under strict compliance and are audited and certified by leading bodies:

GMP & ISO Certificates: Ensures batch-to-batch consistency and a fully auditable manufacturing process.
HACCP & ORGANIC Certification: Guaranteeing safe food-grade processing and trace-back capability to agricultural origins.
FDA Registration: Facilitates customs clearance for domestic distributors and global logistics hubs.
HALAL & KOSHER Certified: Ensuring compliance with dietary and religious guidelines worldwide.

Global Warehousing & Localization Support

Recognizing the complexities of international trade, TRB has established localized support networks and flexible logistic agreements:

DF/DDP Delivery Options: Our team handles export licensing, custom clearance, tariffs, and inland transport to minimize friction for international buyers.
Strategic Warehousing: Maintained inventory in key domestic and international logistical nodes ensures standard materials are dispatched within 48 hours of order confirmation.
Customized Formulation & Particle Size: We offer customizable particle sizes (e.g., micronized powder at 80-120 mesh for enhanced bioavailability) and customized concentration ratios to suit specific client applications.
Comprehensive Analytical Documentation: Every shipment is dispatched with an authentic Certificate of Analysis (COA), Safety Data Sheet (SDS), residual solvent reports, and heavy metal testing profiles.

Ursolic Acid Industrial FAQ (Q&A)

Answering crucial technical, formulation, and commercial questions for sourcing managers and R&D scientists.

What is the primary botanical source of TRB’s Ursolic Acid, and how do you prevent isomerization with Oleanolic Acid?

Our Ursolic Acid is primarily extracted from premium *Rosmarinus officinalis* (Rosemary) leaves and *Eriobotrya japonica* (Loquat) leaves. Because Ursolic Acid and Oleanolic Acid are structural isomers, separating them requires high-performance column chromatography. At TRB, we utilize specialized stationary phase chromatography resins that successfully separate the two isomers, allowing us to consistently offer high-purity Ursolic Acid (up to 98% HPLC) with Oleanolic Acid levels kept below 1.5% or as specified.

What solvent limits do your production lines adhere to, and how is safety verified?

Our production processes follow green chemistry guidelines, using water and food-grade ethanol as the extraction solvents. We strictly exclude toxic Class 1 solvents like benzene and Class 2 solvents like hexane or methanol. Every batch is analyzed using Gas Chromatography with Flame Ionization Detection (GC-FID) to verify that residual ethanol is well within USP <467> and EP guidelines (typically under 500 ppm, far below the regulatory limit of 5,000 ppm).

How does TRB ensure batch stability and shelf-life compliance?

Our Ursolic Acid has a documented shelf life of 24 to 36 months when stored in its original, unopened packaging in a cool, dry place. We perform real-time and accelerated stability studies in compliance with ICH guidelines. The powder is packaged in double-layered food-grade polyethylene bags and sealed within fiber drums to protect the compound from light, moisture, and air exposure.

What is the MOQ (Minimum Order Quantity) and your typical delivery lead time?

For standard specification powders (50%, 90%, 98%), our standard MOQ starts at 1 kg for validation and pilot trials, with commercial scale packaging starting at 25 kg per drum. For standard stock items, dispatch occurs within 3 to 5 business days from our Nanjing warehouse. Custom orders or micronized grind requests typically require 10 to 15 business days depending on production scheduling.

How does Ursolic Acid behave in formulation, and can you improve its water solubility?

Naturally, Ursolic Acid is lipophilic and has low solubility in water, but dissolves readily in hot alcohol, DMSO, and organic solvents. To address formulation challenges in sports nutrition and functional beverages, TRB offers specialized water-dispersible grades. We use advanced clean-label carriers and natural emulsifiers to improve its dispersion in water, helping formulators maintain high bioavailability in liquid systems.