Derived from the near-ripe fruit of Evodia rutaecarpa (Wu Zhu Yu), Evodia Extract stands as a cornerstore of traditional Eastern pharmacopoeias, now widely integrated into modern pharmaceutical chemistry and dietary supplement formulations. Under scientific scrutiny, the extract is prized for its high density of bioactive quinolone alkaloids, primarily Evodiamine and Rutaecarpine. These compounds display a multifaceted therapeutic profile, acting as natural agonists for transient receptor potential vanilloid-1 (TRPV1) channels, inhibitors of inflammatory cytokines, and potent modulators of vascular and metabolic homeostasis.
As a premier global supplier, Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) utilizes state-of-the-art chromatographic extraction techniques to yield standardized Evodia Extract. We offer standard ratios (10:1, 20:1) as well as highly purified isolates containing up to 98% Evodiamine or Rutaecarpine, tailored for targeted pharmacological and clinical applications.
In the global market, sourcing pure, unadulterated Evodia Extract is critical. Due to the complex nature of quinolone alkaloids, standard botanical powders can suffer from high levels of volatile impurities or microbial loads. TRB's specialized refinement pathway strips out unnecessary heavy starches and unwanted tannins, concentrating the therapeutic components while guaranteeing maximum bio-absorption. This is why multinational dietary supplement brands trust TRB as their long-term supply chain partner.
Different target industries demand distinct standardization ratios and physical properties. TRB provides tailor-made solution pathways:
Evodiamine acts as a natural thermogenic agent. Through mild stimulation of TRPV1 receptors, it accelerates metabolic rate and fat oxidation, making it a foundational ingredient in premium weight-management products and pre-workout formulas.
Rutaecarpine significantly stimulates nitric oxide (NO) production within endothelial cells, promoting vasodilation, improving microcirculation, and acting as an excellent functional ingredient for blood pressure support formulations.
The raw alkaloids inhibit cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), dampening pro-inflammatory cascades. This property makes it highly effective in targeted joint-comfort supplements and topical patches.
Emerging neurobiological research suggests Evodiamine and related compounds support brain health by optimizing cerebral blood circulation, protecting against oxidative stress, and supporting memory pathways.
The future of herbal supplementation lies in high bioavailability and eco-conscious manufacturing. Traditional extraction methods often utilize excessive organic solvents, leaving high levels of residue. TRB's technical roadmap outlines our path toward zero-residual, ultra-bioavailable bioactive compounds.
By applying supercritical CO2 extraction combined with food-grade ethanol as a co-solvent, we successfully isolate Evodiamine and Rutaecarpine without heavy chemical solvent contact, preserving the botanical's thermodynamic integrity.
Pure Evodiamine is hydrophobic, which naturally limits its absorption rate in the human digestive system. Our R&D division has developed micro-encapsulated formulations, boosting cellular uptake by up to 250% compared to standard powders.
As a pioneer in botanical technology, TRB is investing in microbial fermentation pathways. This will allow for the scale-up of pure isolated alkaloids independent of seasonal climate shifts, stabilizing long-term supply costs.
In an era of volatile trade landscapes, reliability is the greatest asset. Operating out of our advanced industrial park in Nanjing, TRB has digitized the plant extraction supply chain from farm to shipping port.
TRB operates three distinct processing plants: one focused entirely on botanical & herbal extracts, one specialized in high-purity bee products, and another dedicated to premium animal extracts. This division guarantees absolute cross-contamination prevention.
Every batch of Evodia Extract undergoes exhaustive High-Performance Liquid Chromatography (HPLC) testing, Gas Chromatography-Mass Spectrometry (GC-MS) for pesticides, and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for heavy metals.
Our plants maintain a comprehensive array of compliance certificates including GMP, ISO, HACCP, ORGANIC, FDA register, HALAL, and KOSHER. We ensure seamless custom clearing across North America, Europe, and Asia-Pacific.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is China's leading manufacturer and exporter of herbal extracts and its derivatives, driving innovation in the market for more than 20 years. We operate as a modern, technology-based company integrating state-of-the-art research and development, smart production lines, and high-efficiency international market sales.
Our comprehensive catalog spans high-efficacy herbal extracts, clean sweeteners, nootropics, standardized vegetable & fruit juice powders, premium essential oils, and organic bee products.
Acknowledged for our rapid industrial scale-up and dedication to quality in the plant extract sector, we are proud recipients of the 2026 "Global Biotechnology and Life Sciences Award" as the ''Best Global Herbal Extract Provider 2026''.
Currently, TRB's production footprint covers three state-of-the-art factories. In recent years, our R&D focus has centered heavily on Nootropics products, including Brain Health Herb Extract, Anti-Aging Herb Extracts, and Longevity Herb Extracts, earning top marks from our enterprise clients globally.
We fulfill the strict demands of global quality controllers, regulatory managers, and corporate buyers.
Every gram of Evodia Extract is traced directly back to high-altitude harvesting locations, ensuring absolute transparency regarding wildcrafting or agricultural harvesting techniques.
No filler, no adulterants. Our high-precision HPLC testing detects the exact active presence of Evodiamine, ensuring our clients pay only for the real active ingredients.
With climate-controlled warehousing facilities and established maritime, air, and express contracts, we guarantee stable transit schedules and protect botanical freshness.
Regulatory landscapes are shifting rapidly. With the European Food Safety Authority (EFSA) and the United States FDA enforcing stricter limits on chemical residues and novel food classifications, raw material sourcing demands a compliance partner. At TRB, we actively manage international regulatory profiles:
Our products conform completely to the USP <561> pesticide limit regulations and USP <467> guidelines governing residual solvents, removing any customs delay risks at destination ports.
We provide complete documentation support, delivering Certificate of Analysis (COA), Safety Data Sheets (SDS), Technical Data Sheets (TDS), Allergen Statements, and GMO-free declarations.
From varying mesh size distributions (80 mesh for capsule formulation, 120 mesh for powder beverages) to private packaging in nitrogen-flushed drums, we customize order variables to fit your processing line.
TRB standardizes Evodia Extract primarily for its dominant quinolone alkaloids: Evodiamine (typically 10% to 98% via HPLC) and Rutaecarpine (up to 98%). We can customize ratios depending on whether your formulation is targeting thermogenic energy, cardiovascular vasodilation, or anti-inflammatory pathways.
We utilize ethanol and water as our primary extraction solvents instead of toxic organic compounds. Any trace solvent is stripped during vacuum concentration and spray-drying phases, ensuring final results measure well below USP guidelines.
The standard shelf life of our Evodia Extract is 24 months when stored in original unopened fiber drums. It should be kept in a cool, dry place away from direct light, heat, and moisture to avoid oxidation of the alkaloids.
Yes. All three of TRB’s manufacturing facilities carry Kosher and Halal validation certifications, facilitating simple market entry in global religious-market dietary segments.
Absolutely. We provide 10g to 50g free evaluation samples for research and development teams to conduct assay verification and formulation trial runs prior to large-scale wholesale procurement.
Evodiamine stimulates TRPV1 receptors similarly to capsaicin, signaling the body to increase internal heat production (thermogenesis). This increases cellular caloric burn without causing central nervous system jitters common in high-caffeine products.
Our standard MOQ for wholesale powder orders is 25kg, packed in a single fiber drum with food-grade double plastic bags inside. We can accommodate smaller test runs under special requests from prospective partners.
We perform botanical identification verification using High-Performance Thin-Layer Chromatography (HPTLC) comparison profiling, matching each raw material batch to official reference standards before it enters our extraction vessels.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
Phone: 86-25-52863298
Mobile: 86-13770771528
86-25-52867040
