| Product Name |
Dehydrocholic Acid |
| CAS No |
81-23-2 |
| Assay |
98.0% Min |
| Colour |
White to off-white powder with characteristic odor and taste |
| GMO Status |
GMO Free |
| Packing |
in 25kgs fiber drums |
| Storage |
Keep container unopened in cool, dry place, Keep away from strong light |
| Shelf Life |
24 months from date of production |
Dehydrocholic Acid: Functions, Applications, and Pharmaceutical Benefits
1. Product Overview
Dehydrocholic Acid (CAS 81-23-2), a synthetic triketo bile acid derivative, is USP-certified for pharmaceutical and research use. As a choleretic agent, it enhances bile secretion and fluidity, making it critical in managing biliary disorders.
2. Key Benefits & Mechanisms
- Increases bile volume by 270% in clinical models through hydrocholeretic action.
- Reduces biliary cholesterol and phospholipid levels by 64-94%, improving bile composition.
- Facilitates bile flow to alleviate bile duct obstruction and cholestasis.
- Metabolized into bioactive hydroxy-keto derivatives for sustained effects.
- Used in pharmacokinetic studies of bile acid metabolism.
- Standard reference material for analytical testing (USP grade).
3. Clinical & Industrial Applications
3.1 Therapeutic Uses
- Biliary Stasis Treatment: First-line option for post-surgical bile flow restoration.
- Cholelithiasis Adjunct: Enhances dissolution of cholesterol-rich gallstones when combined with ursodeoxycholic acid.
- Diagnostic Aid: Historical use in "Decholin®" for hepatic function testing.
3.2 Pharmaceutical Formulations
- Injectable solutions (pH 9-11) meeting USP standards for hospital use.
- Oral tablets compounded with alkaline buffers to improve solubility.
4. Safety & Handling
- Classified as Acute Toxicity Category 4 (Oral) and Skin Irritant Category 2.
- Requires PPE (gloves, goggles) and handling in ventilated facilities.
Download full SDS.
5. Packaging & Supply
- Available in research (1mg-100mg) and bulk quantities (25kg/50kg fiber drums).
- Custom synthesis and purity levels (≥95%) upon request.
6. Why Choose Our Product?
- USP-verified quality with batch-specific COA.
- Supported by 50+ years of clinical research (e.g., Soloway et al. 1973).
- Globally compliant: FDA-recognized and EU GMP-certified manufacturing.
Frequently Asked Questions (FAQ)
Q:
What is the primary function of Dehydrocholic Acid?
Dehydrocholic Acid acts as a choleretic agent, which stimulates the secretion and fluidity of bile. This mechanism makes it key for managing biliary disorders and enhancing overall biliary flow.
Q:
Is Dehydrocholic Acid suitable for clinical diagnostics?
Yes, Dehydrocholic Acid has a history of use as a diagnostic aid under formulations such as "Decholin" specifically for evaluating hepatic function.
Q:
What are the handling and safety requirements?
It is classified as an Acute Toxicity Category 4 (Oral) and Skin Irritant Category 2 substance. Only trained professionals should handle it using proper Personal Protective Equipment (PPE) such as safety gloves and goggles, and it should always be managed in properly ventilated facilities.
Q:
How does it support the treatment of gallstones?
It serves as a therapeutic adjunct in cholelithiasis. When combined with ursodeoxycholic acid, it helps improve the dissolution rate of cholesterol-rich gallstones.
Q:
What packaging sizes and custom features are available?
We offer research scales ranging from 1mg to 100mg, as well as bulk commercial orders packed in 25kg or 50kg fiber drums. Custom synthesis with purity thresholds of 95% or higher is also available upon customer request.
Q:
What are the storage guidelines and shelf life for this product?
Keep the container unopened and store it in a cool, dry place. Ensure it is protected from strong light. The shelf life is 24 months from the production date under these recommended storage conditions.
