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Understanding the science, market dynamics, and therapeutic potential driving global B2B demand.
Fisetin (7,3',4'-tetrahydroxyflavone) is a naturally occurring dietary flavonoid found in various fruits and vegetables, such as strawberries, apples, persimmons, and onions, as well as in trees and shrubs like Cotinus coggygria (Smoketree). In recent years, Fisetin has emerged as one of the most researched and sought-after compounds in the longevity and healthy aging sector. This surge in interest is primarily driven by its potent senolytic properties—its ability to selectively induce apoptosis in senescent cells without harming healthy cells.
As the global population ages, the demand for preventative health solutions has shifted from simple vitamin supplementation to targeted cellular rejuvenation. Cellular senescence, a state of permanent cell cycle arrest, is a primary driver of age-related tissue degeneration and chronic inflammation (often referred to as "inflammaging"). By clearing these "zombie cells," Fisetin helps restore tissue homeostasis, supports cognitive function, and promotes cardiovascular health. Consequently, dietary supplement brands, cosmetic formulators, and pharmaceutical researchers worldwide are actively integrating high-purity Fisetin powder into their product pipelines.
"The global anti-aging and longevity market is projected to reach over USD 44 billion by 2030. Fisetin, alongside other senolytics like Quercetin and Apigenin, represents the vanguard of this therapeutic expansion, transitioning from niche research chemicals to mainstream active ingredients."
For procurement officers and product formulators, sourcing high-quality, standardized Fisetin powder is critical. The efficacy of the final product depends entirely on the purity, stability, and safety profile of the raw material. As a leading manufacturer, Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) provides state-of-the-art extraction and purification technologies to deliver Fisetin powder that meets the most stringent international regulatory standards.
Your Trusted Partner in High-Purity Botanical Extraction for Over Two Decades
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a leading China-based manufacturer and exporter of premium herbal extracts and their derivatives, boasting over 20 years of industry expertise. We operate at the intersection of biotechnology and natural product chemistry, combining rigorous research and development, advanced manufacturing capabilities, and seamless international sales and logistics.
Our product portfolio is diverse and highly specialized, covering Herbal Extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice Powders, Essential Oils, and Bee Products. Over the years, our rapid development and unwavering dedication to quality have earned us prestigious recognition, including the 2026 Global Biotechnology and Life Sciences Award as the "Best Global Herbal Extract Provider 2026".
TRB operates three specialized manufacturing facilities: a dedicated herbal extract factory, a bee product factory, and an animal extract processing facility. To ensure absolute safety, efficacy, and compliance with global markets, our facilities hold a comprehensive suite of international certifications, including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER.
In recent years, TRB has focused heavily on the research and development of Nootropics and cellular health products. Our Brain Health Herb Extracts, Anti-Aging Herb Extracts, and Longevity Herb Extracts have received exceptional feedback from global clients, positioning us as a key supply chain partner for leading health and wellness brands in over 60 countries.
High-purity manufacturing processes designed for maximum stability and bioavailability.
At TRB, our Fisetin Powder is primarily extracted from the stems and leaves of Cotinus coggygria (Smoketree) using an advanced, eco-friendly solvent extraction process. This is followed by multiple crystallization and purification steps to achieve a standard purity of ≥98% by HPLC. We also offer customized specifications to meet the unique formulation needs of our clients.
| Specification Parameter | Standard Value / Limit | Testing Method |
|---|---|---|
| Product Name | Fisetin Powder (Cotinus coggygria Extract) | Visual / Identity |
| Active Ingredient | Fisetin (≥98.0%) | HPLC |
| CAS Number | 528-48-3 | Reference Standard |
| Appearance | Yellow to fine yellow crystalline powder | Visual |
| Loss on Drying | ≤1.0% | USP <731> |
| Heavy Metals | ≤10 ppm (Pb ≤1.0 ppm, As ≤1.0 ppm, Hg ≤0.1 ppm) | ICP-MS |
| Residual Solvents | Meets USP/EP requirements (Ethanol ≤5000 ppm) | GC-MS |
| Total Plate Count | ≤1,000 cfu/g | USP <61> |
| Yeast & Mold | ≤100 cfu/g | USP <61> |
| E. Coli & Salmonella | Negative / Absent in 10g | USP <62> |
Our quality assurance protocol is integrated into every step of the manufacturing process. From raw material sourcing and botanical identification to extraction, concentration, purification, and packaging, every batch undergoes rigorous testing. We utilize high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and inductively coupled plasma mass spectrometry (ICP-MS) to guarantee chemical purity, identify potential contaminants, and ensure the absence of heavy metals, pesticides, and solvent residues.
Meeting the complex regulatory, logistical, and volume requirements of global enterprises.
With clients in over 60 countries, TRB has developed a highly efficient global logistics network. We offer flexible shipping terms (FOB, CIF, DDP, FCA) and partner with leading international freight forwarders to ensure timely and secure delivery by air, sea, or express courier. We handle all export documentation, customs clearance, and transit insurance to minimize lead times.
We understand that different applications require different physical properties. TRB offers custom particle sizing (micronization) to improve solubility and blending uniformity, custom packaging options (from 1kg aluminum foil bags to 25kg fiber drums), and contract manufacturing services for pre-blended formulations (e.g., Fisetin + Quercetin co-formulations).
Navigating international regulatory landscapes can be challenging. TRB provides comprehensive documentation support, including Certificates of Analysis (COA), Material Safety Data Sheets (MSDS), Technical Data Sheets (TDS), Allergen Statements, GMO-Free Declarations, and BSE/TSE Free Certificates. Our regulatory team assists with product registrations and compliance audits.
How global brands leverage Fisetin to create high-value, scientifically backed consumer products.
Fisetin's versatile biological activities make it an ideal active ingredient across multiple industries. Below are the primary sectors driving commercial demand:
This is the largest market for wholesale Fisetin. Formulators typically position Fisetin as a cellular rejuvenator, healthy aging support agent, or senolytic complex. It is frequently combined with other synergistic compounds to enhance its biological effects:
Emerging clinical and preclinical research indicates that Fisetin can cross the blood-brain barrier, promote long-term potentiation, protect neurons from oxidative stress, and support overall cognitive function. It is increasingly incorporated into premium brain health supplements, memory enhancers, and focus formulas targeted at both aging demographics and young professionals seeking cognitive optimization.
In the cosmetics industry, Fisetin is utilized in topical formulations (creams, serums, and anti-aging lotions) due to its powerful antioxidant, anti-inflammatory, and collagen-protective properties. By reducing the senescence-associated secretory phenotype (SASP) in skin cells, Fisetin helps maintain skin elasticity, reduce the appearance of fine lines and wrinkles, and protect the skin barrier from UV-induced photoaging.
Addressing bioavailability challenges and pioneering next-generation delivery systems.
Despite its remarkable therapeutic potential, free Fisetin exhibits relatively low oral bioavailability, primarily due to its poor water solubility and rapid first-pass metabolism in the liver. To overcome these limitations, TRB's R&D division is actively working on several advanced formulation technologies:
Encapsulating Fisetin within phospholipid bilayers (liposomes) significantly enhances its solubility, protects it from degradation in the digestive tract, and facilitates direct cellular absorption, resulting in up to a 5-fold increase in bioavailability.
By reducing the particle size of Fisetin to the sub-micron or nanometer scale and coating it with food-grade polymers, we can drastically increase its surface area, dissolution rate, and systemic absorption profile.
Developing isotropic mixtures of oils, surfactants, and co-solvents that spontaneously form fine oil-in-water emulsions upon contact with gastrointestinal fluids, ensuring rapid and consistent absorption of the active compound.
Looking forward, TRB is committed to investing in clinical trials and efficacy studies to further validate the safety and performance of these advanced delivery formats. Our goal is to provide global formulators with highly bioavailable, clinically backed Fisetin raw materials that deliver measurable health outcomes for consumers.
Ensuring seamless integration into local markets with strict adherence to international standards.
Operating a global supply chain requires deep local knowledge and strict compliance with regional regulations. TRB has established dedicated compliance teams to support our clients in key markets, including North America, Europe, Asia-Pacific, and Latin America.
In the US, dietary ingredients must comply with the Dietary Supplement Health and Education Act (DSHEA). TRB provides full documentation to support New Dietary Ingredient (NDI) notifications and ensures that our manufacturing processes align with current Good Manufacturing Practices (cGMP) under 21 CFR Part 111. Our facilities are FDA-registered, and we regularly host third-party audits from US-based clients.
The EU market has some of the strictest regulations for botanical extracts. TRB closely monitors the European Food Safety Authority (EFSA) guidelines. We assist our European clients with Novel Food applications, providing detailed toxicological data, characterization studies, and manufacturing consistency reports to ensure smooth regulatory clearance.
To build absolute trust, TRB collaborates with independent, ISO 17025-accredited third-party testing laboratories (such as SGS, Eurofins, and NSF) to verify our in-house analytical results. We can arrange for batch-specific third-party testing for purity, heavy metals, pesticides, and microbiological parameters prior to shipment, providing our clients with independent verification of quality.
Technical and commercial answers to help you make informed procurement decisions.
High-quality botanical extracts and powders to diversify your product offerings.
Get in touch with our sales and technical teams today to request samples, quotes, or technical documentation.
Whether you are looking for a reliable long-term contract manufacturer or need a spot shipment of high-purity Fisetin powder, our team is here to assist you. We respond to all inquiries within 24 business hours.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
Office: 86-25-52863298 | Mobile: 86-13770771528
Fax: 86-25-52867040
