Product Name
Diosmetin 98%
Botanical Source
Citrus aurantium L, Lemon extract
Assay
Diosmetin 98% 99% by HPLC
Colour
Yellow brown to Brown fine powder with characteristic odor and taste
Packing
In 25kgs fiber drums
Storage
Keep container unopened in cool, dry place. Keep away from strong light.
Shelf Life
24 months from date of production
Natural Lemon Peel Extract Diosmetin: Antioxidant & Multifunctional Bioactive Compound
Harnessing Citrus Power for Health and Wellness
Product Overview
Diosmetin (CAS: 520-34-3) is a natural O-methylated flavone primarily derived from lemon peel (Citrus limon) and other citrus fruits. With a molecular formula of C16H12O6 and purity ≥98% (HPLC), it appears as a light-yellow powder, soluble in DMSO, ethanol, and acetonitrile. This compound is celebrated for its diverse pharmacological activities, validated by extensive scientific research.
Key Benefits & Applications
1. Potent Antioxidant Activity
Diosmetin exhibits exceptional free radical scavenging capacity, surpassing vitamin C in neutralizing DPPH and ABTS radicals. Its antioxidant efficacy is quantified via the FRAP assay (Ferric Reducing Ability of Plasma), a gold-standard method for measuring antioxidant power. Applications include:
- Dietary supplements to combat oxidative stress.
- Skincare formulations to protect against UV-induced skin aging and enhance collagen density.
2. Anti-Inflammatory & Anti-Cancer Properties
- Inhibits IL-1β-induced inflammation in chondrocytes, showing promise for osteoarthritis treatment.
- Suppresses tumor growth and angiogenesis in melanoma models by modulating CYP1A1/CYP1B1 enzymes and reducing ROS levels.
3. Cardioprotective & Diuretic Effects
- Protects myocardial cells from oxidative damage via activation of Nrf2/HO-1 pathways.
- Demonstrates dose-dependent diuretic activity in animal studies, comparable to furosemide, with minimal side effects.
4. Bone Health & Anti-Osteoporosis
- Regulates bone formation and mitigates subchondral bone loss in OA models.
Technical Specifications
| Parameter |
Details |
| Purity |
≥98% (HPLC) |
| Solubility |
DMSO (60 mg/mL), Ethanol (17 mg/mL), Water (<1 mg/mL) |
| Storage |
2-8°C in airtight container |
| Safety |
Non-hazardous per EU Regulation (EC) No. 1272/2008; safe for research use |
Sustainable Production
Diosmetin is synthesized through eco-friendly extraction from citrus peel waste (e.g., orange albedo), achieving high yields (73% from hesperidin) via hydrolysis and oxidation. This aligns with circular economy principles, reducing agricultural waste.
Why Choose Our Diosmetin?
- Clinically Validated: Backed by in vitro and in vivo studies on anti-inflammatory, anticancer, and antioxidant effects.
- Versatile Applications: Suitable for nutraceuticals, cosmetics, and pharmaceuticals.
- Quality Assurance: Batch-specific COA available, ensuring traceability and compliance.
Frequently Asked Questions (FAQ)
What is the botanical source of Diosmetin?
Diosmetin is a natural bioflavonoid compound primarily extracted from citrus peel waste, such as Lemon extract (Citrus limon) and Citrus aurantium L.
How is your Diosmetin produced sustainably?
Our Diosmetin is produced using eco-friendly extraction methods from citrus peel waste. It achieves a high 73% yield from hesperidin via hydrolysis and oxidation, supporting circular economy practices by reducing agricultural waste.
What are the main skin benefits of Diosmetin?
Due to its high antioxidant activity, Diosmetin is used in cosmetic formulations to protect the skin from UV-induced aging and support collagen density.
What is the solubility profile of Diosmetin?
Diosmetin is highly soluble in DMSO (60 mg/mL) and Ethanol (17 mg/mL), but has very low solubility in water (less than 1 mg/mL).
How should Diosmetin be stored to maintain its shelf life?
For long-term stability, keep the container unopened in a cool, dry place away from strong light. The recommended temperature is 2-8°C in an airtight container for a shelf life of up to 24 months.
Is the product GMO Free?
Yes, our Diosmetin 98% is fully GMO Free and is packed safely in 25kgs fiber drums.
